World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility
نویسندگان
چکیده
منابع مشابه
Antimalarial drug resistance
Antimalarial drug resistance is of great concern in the WHO South-East Asia (SEA) Region. A high degree of resistance of Plasmodium falciparum to chloroquine and sulfadoxine-pyrimethamine is prevalent in this Region. Multidrug resistance is prevalent in some parts of the Greater Mekong Sub-region. Artemisinin and its derivatives in combination with other effective partner drugs, which showed fa...
متن کاملAntimalarial drug resistance.
Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill between one and two million people, mainly children, each year. Resistance has emerged to all classes of antimalarial drugs except the artemisinins and is responsible for a recent increase in malaria-related mortality, particularly in Africa. The de novo emergence of resistance can be prevented by ...
متن کاملAntimalarial Drug Resistance
Malaria is a hematoprotozoan parasitic infection transmitted by certain species of anopheline mosquitoes. Four species of Plasmodium commonly infect humans, but Plasmodium falciparum, accounts for the majority of instances of morbidity and mortality. There has been a resurgence of interest in malaria in recent years because the efforts at control have foundered after the failure of the global e...
متن کاملHigh-throughput analysis of antimalarial susceptibility data by the WorldWide Antimalarial Resistance Network (WWARN) in vitro analysis and reporting tool.
Assessment of in vitro susceptibility is a fundamental component of antimalarial surveillance studies, but wide variations in the measurement of parasite growth and the calculation of inhibitory constants make comparisons of data from different laboratories difficult. Here we describe a Web-based, high-throughput in vitro analysis and reporting tool (IVART) generating inhibitory constants for l...
متن کاملIn vitro antimalarial susceptibility and molecular markers of drug resistance in Franceville, Gabon
BACKGROUND Malaria remains a major public health problem, due largely to emergence and widespread P. falciparum drug resistance. WHO recommends artemisinine combination based therapy (ACT) to overcome P. falciparum drug resistance, but reports of declining ACT efficacy have been published. A thorough understanding of the molecular bases of P. falciparum resistance to existing drugs is therefore...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2007
ISSN: 1475-2875
DOI: 10.1186/1475-2875-6-120